An experimental study was done to investigate the spontaneous movements to the isolated ileum with liquid extracts of Samchulgunbitang. Then the action of gastric ulcer, gastric-juice secretion, the free acidity, total acidity, pepsin output, the transport ability in the intestine, analgesic effect and sleeping time were measured.
The following results were obtained;
1. As to the spontaneous movements in the isolated ileum, the effect of contraction against suppression was recognized.
2. The effects of contraction against suppression induced by acetylcholine chloride and barium chloride were recognized on the gastric funds strip significantly.
3. The preventive effect of Samchulgunbitang on the pylorus-lightedulcer in rat was recognized significantly.
4. The anti-ulcer effect of Samchulgunbitang was not recognized on the gastric ulcer caused by indomethacin.
5. The effects of decreasing on the secretion gastric juice, the free acidity, total acidity and pepsin output of Samchulgunbitang were recognized significantly.
6. The transport rate in the small intestine of Samchulgunbitang was decreased.
7. The transport rate in the large intestine of Samchulgunbitang was increased.
8. The analgesic effect of Samchulgunbitang caused by acetic acid was recognized significantly.
9. The sleeping time caused by pentobarbital-Na of Samchulgunbitang was prolonged significantly.
According to the results, it is considered that the Samchulgunbitang has effects of gastric ulcer, chronic gastritis, hyper-acidity, gastroptosis such as abdominal discomfort, gastric acid, indigestion and anorexia.
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